A Direct and Simple Approach for the Synthesis of Indole-3-propanol and Its Acetates from Dihydropyran.

A general method was developed for the one-pot synthesis of highly functionalized indoles from simple, commercially available phenylhydrazine hydrochlorides and dihydropyran. Synthesis of indole-3-propanol and its acetates was studied extensively for appropriate acetic acid and water mixture as the solvent.