A facile one-pot synthesis of L-DOPA imprinted silica nanospheres for chiral separation and in vitro controlled release

A one-pot methodology was successfully developed to synthesize chiral imprinted silica nanospheres with hollow and mesoporous structures. These silica nanospheres demonstrated high capacity and chiral selectivity for L- or D-3,4-dihydroxyphenylalanine (L- or D-DOPA) and possessed potency for L-DOPA controlled release.