High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.
2014
Paul Meltzer and colleagues report the results of an exome sequencing study of variant and IGHV4-34–expressing hairy-cell leukemias. They identify a high frequency of activating MAP2K1 mutations in these malignancies, suggesting potential therapeutic strategies.
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