Flavonoids from ethyl acetate extract of Echinops spinosus (Asteraceae)

The aim of the present study was the phytochemical investigation of the ethyl acetate (EtOAc) soluble parts of the aqueous-MeOH extract of the aerial parts of Echinops spinosus L. (Asteraceae). This work resulted in the isolation and identification of three known compounds, Apigenin(1), Apigenin-7-O-β-glucopyranoside (cosmosiin) (2) and apigenin-7-β-D-O-(6’’-O-E-p-coumaroyl)-glucopyranoside (3). The structures of the compounds were determined on the basis of extensive spectroscopic analysis, including UV, 1D and 2D NMR and comparison with the related known compounds. All these compounds are isolated from this species for the first time.