Central nervous system activity of first-line osimertinib in epidermal growth factor receptor-mutant advanced non-small cell lung cancer
2019
Although the majority of patients with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)- sensitizing mutations experience good initial response to first‑generation (erlotinib, gefitinib) and second-generation (afatinib, dacomitinib) EGFR-TKIs, they invariably suffer disease progression either due to a pharmacodynamic resistance to the EGFR-TKI or a pharmacokinetic failure resulting in central nervous system (CNS) progression (1-3).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
22
References
5
Citations
NaN
KQI