Original article Smoking influences response to inhaled corticosteroids in patients with asthma: a meta-analysis

Objective: To determine the effects of smoking on efficacy of inhaled corticosteroids in asthmatics. (SMD ¼� 0.197, 95% CI: (� 0.327, � 0.066), p ¼0.003), morning PEF (SMD ¼� 0.796, 95% CI: (� 1.047, � 0.545), p50.001), night-time PEF (SMD ¼� 0.501, 95% CI: (� 0.797, � 0.204), p ¼0.001) and post-treatment FEV1 (SMD ¼� 0.178, 95% CI: (� 0.309, � 0.046), p ¼0.008) and increased use of concomitant medications (SMD ¼0.537, 95% CI: (0.166, 0.908), p ¼0.005) in smokers, but not non-smokers with asthma, although there was no statistical difference in allergy- related endpoints and asthma score (ACQ-5).