The Comparison of Serum Uric Acid Level in Patients with Diabetic Neuropathy with Diabetics without Neuropathy

Introduction: Diabetes type 2 and it, s complication, diabetic neuropathy, is increasingly a health threatening problem in the world. The increase in blood uric acid levels has accompanied endothelial malfunction, ischemic heart disease, brain stroke, peripheral artery disease and mortality cause by coronary vessels disease. We studied the effects of uric acid on diabetic neuropathy in type 2 diabetics. Methods: 135 diabetics type II referring to Golestan Hospital divided in two groups: "neuropathics"(65 patients) and "without neuropathy"(70 patients). Serum uric acid, ESR and qualified CRP was measured and compared between two groups. Results: the comparison of mean ESR in both groups showed a meaningful higher level of ESR in case group rather than control group (p-value: 0.003) But there wasn’t any meaningful difference in qualitative CRP evaluation between two groups, The uric acid serum levels of case group patients were meaningfully higher than control group patients (p value > 0.0001). A meaningful correlation of ESR and serum uric acid level was seen also in this research, but there wasn’t any meaningful correlation between ESR and serum uric acid level in control group patients. Conclusion: It seems that serum level of uric acid can be as a predicting factor for diabetic neuropathy. Key words: Diabetic Neuropathy, Serum Uric Acid