Physiological and pathophysiological role of histamine in the gastrointestinal tract

: In this paper, the authors discuss problems concerning the role played by histamine in various physiological and pathological processes in the gastrointestinal tract. The synthesis and metabolism of histamine is described. Apart from participation in many physiological processes, e.g. secretion of gastric juice, histamine takes part in many pathological reactions occurring in celiac disease, food allergy and inflammatory bowel diseases.