Clinical Effect of Intensity Modulated Radiation Therapy Combined with Concomitant and Adjuvant Temozolomide in the Treatment for Malignant Glioma

[Purpose] To investigate clinical efficacy of intensity modulated radiation therapy(IMRT) combined with concomitant and adjuvant temozolomide(TMZ) in the treatment for malignant glioma.[Methods] A total of 28 malignant glioma cases(grade Ⅲ～Ⅳ) pathologically proved were enrolled.After 40Gy/20f/4w by conventional fractionation irradiation delivered through whole brain left/right fields,IMRT was started as a boost.The irradiation dose of doseescalation was 20Gy/4f/2w;TMZ was given for 6 cycles at the same time,then at least 2 cycles by the routine treatment.[Results] The median survival time and the progression free survival time were 11.5 months and 7.2 months respectively.1-year and 2-year survival rate were 53.57% and 25.00% respectively.The common side effects were nausea,vomiting;hematologic toxicity was white cells and platelets decreased(degreeⅠ～Ⅱ).[Conclusion] IMRT plus concomitant and adjuvant TMZ for malignant glioma is safe and effective,with mild adverse reactions.