Drug delivery particles and manufacturing method thereof

In the hollow capsid, while holding the initial infection activity of the virus, an object conveniently nucleic acids to develop and provide a method to incorporate peptides and / or low molecular compounds. Hollow capsid or hollow particles with the nucleic acid in a solution containing 0.1 to 20% of a surfactant, admixing agents including peptide and / or a low molecular compound, and the resulting mixture maintained at -5 to 50 ° C. and, to provide a method of manufacturing a drug delivery particle comprising introducing the drug into the hollow capsid or hollow particles.