Effect of Transfer Factor Therapy on Mix

We have studied the effect of dialyzable transfer factor therapy on three patients with immuno- deficiency disease and in one patient who demonstrated no evidence of deficiency of either humoral or cellular im- munity. We found evidence for nonspecificity in the effect of transfer factor on mixed lymphocyte culture reactivity. The data suggest that in patients with immunodeficiency disease a maturation of lymphocytes may lead to a gen- eralized increased immune responsiveness. More pro- foundly, our data show that transfer factor may induce changes in the expression of histocompatibility determi- nants. We observed changes in the expression of deter- minants capable of stimulating in the mixed lymphocyte culture reaction as well as an increase in the capacity of lymphocytes to respond.