Kemokini CXCL10 i CXCL11 u patogenezi enterovirusnoga meningitisa [Chemokines CXCL10 and CXCL11 in the pathogenesis of enteroviral meningitis]

Aim: To define the role of chemokines CXCL10 and CXCL11 and chemokine concentration gradient between the peripheral blood and CNS in immunopathogenesis of non polio enteroviral aseptic meningitis (NPEV AM). Patients and methods: The study included 84 pediatric patients; 55 with NPEV AM and 29 controls in whom CNS infection has been excluded by negative CSF examination.The NPEV etiology has been proven by detection of enteroviral RNA using real-time PCR method. Chemokines were quantified by using standardized enzyme immunoassay. Results: Concentrations of CXCL10 (median 21.3 ng/mL) and CXCL11 (median 0.24 ng/mL) in CSF samples of children with NPEV AM (0.27 ng/mL) were higher in comparison to control group (CXCL10 median 0.26 ng/mL, CXCL11 median 0.21 ng/mL). CXCL10 concentrations in the sera of NPEV AM group (median 0.27 ng/mL) and controls (CXCL10 median 0.21 ng/mL) did not differ significantly. CXCL11 sera concentrations were equal or slightly lower within NPEV AM group. Positive correlation between CSF CXCL10 concentrations or CXCL10 CSF-plasma gradient (median 60.9 ng/mL) and CSF pleocytosis in patients with NPEV AM was determined as well. Conclusion: CXCL10 and CXCL11 concentration gradient between the CSF and plasma in children with NPEV AM suggests an important role of these chemokines in the T-cells recruitment into the CNS and local immunoreaction.