Relationships between food effects, patient adherence to treatment, and pharmacokinetics of oral anticancer drugs.

e17614 Background: Taking oral anticancer drugs with food has the potential to influence their bioavailability and exposure. The objective of this literature review was to identify oral anticancer drugs with food restrictions in the label, to assess the effects of food on their pharmacokinetics, and to explore food restrictions as a potential barrier to adherence. Methods: A review of U.S. Food and Drug Administration (FDA) labels identified oral anticancer drugs with food restrictions. The effect of food on exposure was quantified by comparing the area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) in fed and fasted states. A systematic literature review identified studies investigating the impact of food restrictions on adherence to treatment; sources included PubMed, EMBASE, and Cochrane Reviews. Results: Among 14 oral anticancer drugs approved by the FDA since 2009, 7 have food restrictions: 4 must be taken without food, 2 must be taken with food, and 1 must be...