Pharmacokinetic evaluation of bioactive compounds present in Indian Bay leaf against Human Aquaporin2

There are more than sixty different types oil extracts reported in Cinnamomum tamala or Indian Bay leaf plant by various researcher that have anti-diabetic, anti-cough effects. The bay leaf found a most widely used plant by various ethnic groups in north east (NE) India. The Aquaporin2 (AQP2) a water channel protein which dysfunction or mutations enhances the failure in water homeostasis in body that leads to nephrogenic diabetes insipidus. Herein we have carried out an in-silico interaction study with some filtrated compounds of bay leaf against the Aquaporin 2 protein so that the protein will regain its normal function. We have generated a 3D structure of this AQP2 protein through multiple templates, then refined the structure and assessed. In-silico docking and pharmacokinetic evaluations have performed with the bay leaf compounds where most of the compounds showing greater results. From these observations it could be suggest that the bay leaf compounds may become potential drug candidate for diabetes insipidus in near future.