Flow cytometric DNA characteristics of radiation colitis--a preliminary study.

The DNA status of 12 rectal biopsies, taken during the investigation of radiation proctitis, was investigated. Of these six were in the acute phase and six in the chronic phase. All of the acute biopsies And diploid DNA, despite bizarre histological epithelial cell appearancer. Two of the chronic phase biopsies wete to have aneuploid DNA profiles. This finding may be relevant to the increased risk of malignancy in irradiated tissues