Progress of research on prognosis evaluation methods in IgA nephropathy

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world. Although it is a chronic progressive disease, the prognosis of individuals varies greatly. Therefore, the prognosis assessment and the end-point event prediction have been hot issues of study. At present, the prognosis-assessing methods of IgAN mainly include pathological classification (Lee′s classification, Oxford classification, etc), clinical indicators (baseline proteinuria, eGFR, etc), mathematical models (ARR score, GOTO model), and biomarkers (urinary TGF-β1, IL-6, etc). A variety of methods provides means for the early prediction and intervention of IgAN prognosis, but each method has its advantages and disadvantages, of which recent research progress was reviewed in this article. Key words: IgA nephropathy; Prognosis; Pathology; Clinical indicator; Biomarker