1356 TRANSMISSION OF HUMAN LIVER SENSITIVITY TO ALCOHOL BY INTESTINAL MICROBIOTA

(164±9 vs. 201±4 pmol/mg tissue) ceramide. Ethanol feeding increased the levels of the phosphorylated forms of ERK slightly, and increased p-p38 and pJNK substantially. The levels of p-p38 and p-JNK levels were reduced by treatment with imipramine. Conclusions: The activation of ASMase and generation of ceramide in response to ethanol feeding may underlie several effects of ethanol. ASmase inhibitor may consider as a therapeutic target for alcohol-induced hepatic steatosis.