PTH treatment induces WNT10b expression in humans lymphoid cells

iPTH increases WNT10b in T cells Our results show a marked increase in WNT10b expression in lymphoid cells during treatment with iPTH, whereas calcium and vitamin D alone has no effect; the increase is maximum after 6 months of treatment. We show that iPTH increases WNT10b production mainly by T cells. cPTH does not affect WNT10b expression In patients affected by primary hyperparatiroidism there was no significant difference in baseline expression as respect to osteoporotic, non-treated patients and surgical intervention does not modify WNT10b expression, data not shown.