The relationship between Neutrophi-Lymphocyte Ratio and in-stent restenosis in superficial femoral artery.

This study aimed to investigate the relationship between an increase in the pre- and post-operative neutrophil - lymphocyte ratio(NLR) and superficial femoral artery in-stent restenosis(ISR) rate. We recruited 199 patients that underwent superficial femoral artery stenting for lower extremity arteriosclerosis obliterans at our hospital from March 2015 to July 2018. Patients were divided into two groups according to the occurrence of ISR within one year (group 1, ISR ; group 2, Non-ISR ). The after NLR (NLRafter)and NLR change ratio (NLRratio) (p  4.3 was associated with an odds ratio of 1.946 (95% CI [1.51 - 2.50]; P  37.5% was associated with an odds ratio of 3.6 (95% CI [2.03 - 6.36]; P 4.3 had 75% sensitivity and 76% specificity for the prediction of ISR, as identified by the ROC curve. A NLRratio level > 37.5% predicted ISR with 77% sensitivity and 60% specificity. Multivariate logistic regression analysis demonstrated that NLRratio was the strongest independent predictor of ISR (p<0.001). In conclusions, NLRratio could be used as a prognostic marker in superficial femoral artery stents.