Distinguishing characteristics of subjects Distinguishing characteristics of subjects with good and poor early outcome in the with good and poor early outcome in the

‘High-risk’studies of schizophrenia have the potential to clarify schizophrenia have the potential to clarify the pathogenesis of schizophrenia.Here, the pathogenesis of schizophrenia.Here, results of extreme outcome groups in the results of extreme outcome groups in the Edinburgh High-Risk Study are presented. Edinburgh High-Risk Study are presented. Aims To compare groups of good and To compare groups of good and poor outcome from the Edinburgh Highpoor outcome from the Edinburgh HighRisk Study and clarify the nature of the Risk Study and clarify the nature of the change from the state of vulnerability to change from the state of vulnerability to that of developing psychosis. that of developing psychosis. Method The recruitment procedure is The recruitment procedure is described.Good and poor outcome are described.Good and poor outcome are defined.These groups are compared in defined.These groups are compared in terms of genetic liability and of baseline terms of genetic liability and of baseline and change in neuropsychology and and change in neuropsychology and neuroanatomy. neuroanatomy.