Corrosion and degradation decelerating alendronate embedded zinc phosphate hybrid coating on biodegradable Zn biomaterials

Abstract An alendronate (AL)-embedded zinc phosphate (ZnP) coating was synthesized on biodegradable Zn to control its corrosion and long-term degradation while maintaining its bio-functionality. The AL molecules were well incorporated into the ZnP and the hybrid coating was homogeneously compact and dense. The coating not only reduced the corrosion current density and the Zn2+ release rate, but also ensured a uniform long-term degradation behavior of Zn in PBS. The coating retained a desirable balanced osteo-functionality of pro-osteoblast and anti-osteoclast response. The above achieved performance can be credited to the nature of the organic-inorganic components of this coating and its high quality.