Substituted aromatic radical biguanide compounds and the application of their medicine composition in preparing medicine for resisting malignant tumors

The present invention relates to substituted aromatic radical biguanide compounds and the application of their medicine composition in preparing medicine for treating malignant tumors. The substituted aromatic radical biguanide compounds possess, extracorporeal and intracorporeal experiments shows, obvious tumor cell inhibiting effect and the features of high efficiency and low toxicity, so that the medicine compounds are expected to be applied in inhibiting tumor attack and metastasis, inhibiting angiogenesis, and treating human melanoma, glioma, lung cancer and other malignant tumors with high expression of integrin.