Catecholaminergic polymorphic ventricular tachycardia with structural heart disease is caused by a mutation in calsequestrin 2 that leads to increased spark-mediated calcium leak in cardiomyocytes

CAR-2 Catecholaminergic polymorphic ventricular tachycardia with structural heart disease is caused by a mutation in calsequestrin 2 that leads to increased spark-mediated calcium leak in cardiomyocytes Aygun Dindar, Oya Uyguner, ES Sahin, D Terentyev, Kemal Nisli, A Uzumcu, R Terentyeva, E Yekeler, S Vedamoorthyrao, A Belevych, S Gyorke, B Wollnik, K Adalet Istanbul University, Istanbul Medical Faculty, Department of Pediatrics, Division of Pediatric Cardiology, Istanbul, Turkey Istanbul University, Istanbul Medical Faculty, Department of Medical Genetics, Istanbul, Turkey Dorothy Davis Heart and Lung Research Institute, Ohio State University, Columbus USA, Ohio, United States Istanbul University, Istanbul, Medical Faculty, Department of Radiology, Istanbul, Turkey Center for Molecular Medicine Cologne (CMMC), Institute of Human Genetics, University of Cologne, Cologne, Germany Istanbul University, Istanbul Medical Faculty, Department of Cardiology, Istanbul, Turkey