FACILITY MANAGEMENT OF A GOOD MANUFACTURING PRACTICE LABORATORY FOR HUMAN CELL AND TISSUE THERAPY: UKM MEDICAL CENTRE EXPERIENCE

Tissue engineering is a well known cross-disciplinary field of regenerative medicine aiming at the replacement, repair or restoration of normal function to diseased organs or tissues by the delivery of safe, effective and consistent therapies composed of living cells, administered either alone or in combination with specially designed materials [1]. After its formation in 2000, the tissue engineering laboratory UKMMC has been awarded as a centre of excellence in research by the Ministry of Higher Education in 2008. The laboratory have focuses on several cell and tissue types such as skin, cartilage and bone have since proven its ability to grow into engineered tissue construct in vitro and in vivo animal model [2-5]. Our first patented product is skin tissue engineering known as MyDermTM, an autologous bilayered human skin substitute with the potential to treat non-healing skin loss such as diabetic ulcers, burns and trauma injuries [5].