Association between Family History Risk Categories and Prevalence of Diabetes in

Abstract Aim Toinvestigate the association betweendifferent familyhistory risk categoriesandpreva-lenceofdiabetesin theChinesepopulation. Methods Thefamilyhistory ofdiabeteswasobtainedfrom eachsubject, andan oralglucose toler-ance testwasperformed formeasuringthe fasting andpostloadglucoseandinsulinlevelsbasedonanational representativecross-sectionalsurveyof46,239individuals(age 20years)inthe2007–2008 ChinaNational Diabetes andMetabolismDisorders Study. Thefamilyhistoryriskcategoriesofdiabeteswere high, moderate,andaverage(FH2 andFH1:atleasttwo generationsandonegenerationoffirst-degreerelatives withdiabetes,respec-tively;FH0: no first-degreerelatives withdiabetes). PLOSONE|DOI:10.1371/journal.pone.0117044 February9,2015 1/13OPENACCESSCitation:ZhangJ,YangZ,XiaoJ,XingX,LuJ,WengJ,etal.(2015)AssociationbetweenFamilyHistoryRiskCategoriesandPrevalenceofDiabetesinChinesePopulation.PLoSONE10(2):e0117044.doi:10.1371/journal.pone.0117044AcademicEditor:HarryZhang,OldDominionUniversity,UNITEDSTATESReceived:September6,2014Accepted:December17,2014Published:February9,2015Copyright:©2015Zhangetal.ThisisanopenaccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.DataAvailabilityStatement:AllrelevantdataarewithinthepaperanditsSupportingInformationfiles.Funding:ThisstudywassupportedbygrantsfromtheChineseMedicalAssociationFoundationandtheChineseDiabetesSociety(grantnumbers:07020470055).Thefundershadnoroleinthestudydesign,datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript.CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist.