Structure-activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors

Abstract A series of N -methyl-bisindolylmaleimide derivatives was synthesized and evaluated as cell death inhibitors. N -Methyl-2-[1-(3-aminopropyl)-1 H -indol-3-yl]-3-(1 H -indol-3-yl)maleimide ( 21 ) was the most potent inhibitor of H 2 O 2 -induced necrotic death of human leukemia HL60 cells among them.