Vaccine containing outer membrane protein of Bordetella pertussis, and method of making such a vaccine.

A VACCINE IN COMPOUND AGAINST disease caused by Bordetella pertussis infection, WHICH IS DEFINED BY: as a first component, pertactin PURIFICADA NOT HAVE adenylate cyclase activity DISCOVERABLE; As an additional component at least one other antigen of B. pertussis IS purified pertussis toxin (PT), filamentous hemagglutinin (FHA) and / or agglutinogens; AS TWO ADDITIONAL COMPONENTS AT LEAST TWO NON-Bordetella Antigens Purified ARE diptheria toxoid (D) and tetanus toxoid (T); And a vehicle pharmaceutically acceptable FOREGOING.