Варианты гена адипонектина ( ADIPOQ ) rs2441766 и rs266729: ассоциация с концентрацией общего и высокомолекулярного адипонектина сыворотки крови у женщин с абдоминальным ожирением и метаболическим синдромом

Background. Adiponectin (AN) - a protective adipocytokine, produced by fat tissue and circulating in the form of various isomers in the blood. With obesity, a decreased level of AN is associated with the development of metabolic syndrome (MS) and various cardiovascular diseases. Regulation of its level can be caused by genetic factors, including single nucleotide polymorphism T(+45)G and C(-11377)G of the ADIPOQ gene. Allelic variants of the ADIPOQ gene was associated with AN concentrarion in blood.Objective. To identify the association of genetic variants of ADIPOQ with adiponectin level, AO and MS in women.Results. A total of 302 women with abdominal obesity (AO) aged 30-55 years were examined. The comparison group consisted of 161 practically healthy women without AO. 185 patients with AO had MS according to the criteria of the International Diabetes Federation (IDF, 2005). The frequencies of genotypes and alleles of variants T (+45) G and C (-11377) G of the ADIPOQ gene among women with and without AO did not differ (p> 0,05). Among women with AO and MS, carriers of G allele variant T (+45) G of the ADIPOQ gene were less common than among women with AO without MS (р 0.05). In women with AO - carriers of the G allele variant T (+45) G of the ADIPOQ gene, the concentration of high molecular weight AN (HMWA) was higher than that of the TT carriers of the genotype of this gene The haplotypes of the T (+45) G and C (-11377) G variants of the ADIPOQ gene did not differ in the studied groups (p> 0,05). The con- centration of total AN in the serum of women with AO and MS - carriers of different genotypes and haplotypes of variants T (+45) G and C (-11377) G of the ADIPOQ gene did not differ (p> 0,05). The concentration of HMWA in women with AO - carriers of the TGC(X) haplotype (X - allele C or G variant C (-11377) G) was higher than in women with AO - carriers of other haplotypes of the ADIPOQ gene (p <0,05). Coclusions. G allele of the T(+45)G variant the ADIPOQ gene is protective against MS in women with AO. In women with AO - carriers of the G allele, the concentration of HMWA is higher than in women with AO - carriers of the TT genotype of variant T(+45)G of the ADIPOQ gene.