Synthesis of new CF3-containing pyridazinone and lactam derivatives

The paper presents the convertion of the bifunctional intermediate γ-keto-thioester (6), into new of pyridazin-3-ones (8) and lactam (9), by reaction with hydrazine derivatives. The structures of all new compounds were ascribed using ID ( 19 F 1 H, 13 C) NMR data that confirmed their structure. The possible reaction mechanisms for the synthesis of pyridazinones (8) and lactam (9) are presented.