Synthesis, molecular modelling studies of indolyl chalcone derivatives and their antimalarial activity evaluation

Jyoti,Rashmi Gaur,Yogesh Kumar,Harveer Singh Cheema,Deepak Singh Kapkoti,Mahendra P. Darokar,Feroz Khan,Rajendra Singh Bhakuni

Synthesis, molecular modelling studies of indolyl chalcone derivatives and their antimalarial activity evaluation

2019

Jyoti
Rashmi Gaur
Yogesh Kumar
Harveer Singh Cheema
Deepak Singh Kapkoti
Mahendra P. Darokar
Feroz Khan
Rajendra Singh Bhakuni

AbstractTwenty one chalcone derivatives were synthesized using Claisen-Schmidt condensation, their antimalarial activity against Plasmodium falciparum was determined and quantitative structure–acti...

Keywords:

Chemistry
Biochemistry
Quantitative structure–activity relationship
Stereochemistry
Chalcone
Plasmodium falciparum
active compound
Biosynthesis
IC50
In vitro
Combinatorial chemistry
molecular mechanism

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