The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study

Shuichi Nawata,Noriko Kohyama,Naoki Uchida,Satoshi Numazawa,Masayuki Ohbayashi,Yasuna Kobayashi,Masanori Iwata,Takanori Nakajima,Hiroshi Saito,Akira Izuka,Toshinori Yamamoto

The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study

2016

Shuichi Nawata
Noriko Kohyama
Naoki Uchida
Satoshi Numazawa
Masayuki Ohbayashi
Yasuna Kobayashi
Masanori Iwata
Takanori Nakajima
Hiroshi Saito
Akira Izuka
Toshinori Yamamoto

Background We formulated mianserin suppositories for the treatment of delirium and evaluated their pharmacokinetics by measuring plasma drug concentrations in dogs and healthy human volunteers.

Keywords:

Medicine
Anesthesia
Rectal administration
Mianserin
Pharmacokinetics
Cmax
Oral administration
Beagle
Suppository
healthy volunteers
Pharmacology

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