Genetic Study of Serum Orosomucoid ( ORM ) Polymorphism by Ultrathin Layer Isoelectric Focusing

Orosomucoid (ORM), or Alpha-1-acid glycoprotein, serum polymorphism, has not been extensively investigated until now,so that ,it is not routinely used in paternity testing. Genetic polymorphism of human serum orosomucoid can be demonstrated with various electrophoretic techniques such as starch gel electrophoresis after protein purification( 1 ), or immunofixation of neuraminidase treated serum ( 2 ), cross Immunoelectrophoresis ( 3 ), separator isoelectric focusing.