0041. The effect of low-dose hydrocortisone after severe burn injury: a microarray longitudinal study

The systemic effect of inflammatory mediators release after severe burn is a severe cardiovascular dysfunction called burn shock. Patients need vasopressor infusion to maintain adequate delivery of oxygen but it could have deleterious effects on skin perfusion and worsen the burn depth. This shock could result from the interplay of the initial hypovolemia and the release of multiple inflammatory mediators. It has been shown that a low-dose of hydrocortisone could reduce the shock duration but the mechanisms involved remain unclear. In this study, we investigated the systemic genomic response after severe burn injuries and determine whether patterns of gene expression could be associated with low-dose of glucocorticoids.