Effect of Pregabalin Use as Preemptive Analgesia after Abdominal Hysterectomy on Heart Rate and Arterial Pressure

Background: Effect of pregabalin on heart rate and arterial pressure is important in its use as preemptive  analgesia. Objective: The purpose of the present study was to evaluate the effect of pregabalin use as  preemptive analgesia after abdominal hysterectomy on heart rate and arterial pressure. Methodology: This  randomized double-blind placebo-controlled clinical trial was conducted in the Department of Anesthesia,  Analgesia and Intensive Care Medicine, Banghabandhu Sheikh Mujib Medical University, Dhaka from July  2010 to June 2012 for a period of two years. Women aged between 40-60 years scheduled for abdominal  hysterectomy under sub-arachnoid block were selected as study population for this study. A total of one  hundred and twenty women meeting the above mentioned criteria were randomly allocated into two equal  groups by card sampling. 120 cards, 60 for each group were prepared by another person who was not aware  of the study. Group A was known as study group who were received 300mg oral pregnabin one hour before  performance of SAB and group B was known as control group who were received matching placebo one  hour before SAB. The patients were examined preoperatively and preoperative baseline parameters including  heart rate, mean arterial pressure were recorded immediately before sub-arachnoid block (SAB). Patients  were visited by the investigators at ½, 1, 2, 4, 12, and 24 h after operation. In each visit, heart rate and mean  arterial pressure were measured and were recorded. Result: The present study was conducted on 120 women  undergoing abdominal hysterectomy. Of them, 60 received preemptive single oral doses (300mg) Pregabalin  (Group A) and the rest 60 received matching placebos (Group B) 1hr before surgery. The mean heart rate  with SD before SAB was 79.4±4.7 and 90.5±5.7 in group A and B respectively (p=0.011). After 24 hours of  operation the mean heart rate with SD was 73±5 and 85±4 in group A and B respectively (p= 0.043). The  mean arterial pressure with SD before SAB was 94.3±5.3 and 95.8±20.4 in group A and B respectively  (p=0.569). After 24 hours of operation the mean arterial pressure with SD was 89.4±4.45 and 96.1±2.56 in  group A and B respectively (p <0.001). Conclusion: In conclusion the mean heart rate and arterial pressure  are statistically significantly changes in the women after abdominal hysterectomy to whom pregabalin is used  as preemptive analgesia. Journal of National Institute of Neurosciences Bangladesh, 2016;2(2): 98-102