Composition of gangliosides in experimental rat tumors

: Spectrum of gangliosides was studied in some tumors. It was the same in a hepatocellular carcinoma induced by N-nitrosomorpholine in Wistar rats as in control liver In addition, several tumors contained an unidentified fraction between GD1b and GT1b. There were total ganglioside differences both in tumours and controls. Lymphatic leukemia samples had lower contents of GD1a and higher contents of GM1 ganglioside. Spontaneous breast sarcoma of Lewis rats (SAM) failed to differ from a sarcoma of low grade malignancy induced by ferridextran (FL) with the exception of slight increase in GD1a and GD2. All the tumours contained higher gangliosides in concentration at least the same as controls.