Effect of Averrhoa bilimbi fruit powder on Histopathology and the Functional Indices of the Liver and Kidney of Rats fed with high fat diet

The effects of Averrhoa bilimbi fruit powder at 125, 250 and 500 mg/kg body weight inhyperlipidemic rats on the histopathology and functional indices of liver and kidney were evaluated. The serum ALT and creatinine were found to be elevated after hyperlipidemic induction in all groups except normal control. However, the ALT and BUN levels were found to be increased with A. bilimbi given at the dose of 500 mg/kg of body weight as well as with rosuastatin group at the end of the experiment.The fruit powder did not significantly (P < .05) alter the creatinine level in the serum of rats. Histological examination revealed mild tubular damage in kidney and marked fatty infiltration along with mononuclear infiltration in the liver and kidney of hyperlipidemic rats. A. bilimbi fruit powder administration exhibited marked reduction in the accumulation of lipid droplets as well as monocytic infiltration in liver and kidney of rats.