Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity

Eun-Young Lee,Hyun-Cheol Lee,Hyun Kwan Kim,Song Yee Jang,Seongjun Park,Yong-Hoon Kim,Jong-Hwan Kim,Jungwon Hwang,Jae-Hoon Kim,Tae-Hwan Kim,Abul Arif,Seon Young Kim,Young Ki Choi,Cheolju Lee,Chul-Ho Lee,Jae U. Jung,Paul L. Fox,Sung Hoon Kim,Jong-Soo Lee,Myung Hee Kim

Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity

2016

tRNA synthetases are essential to protein synthesis. Kim and colleagues identify a non-translational function for glutamyl-prolyl-tRNA synthetase during viral infection that promotes the anti-viral activity of the antiviral signaling protein MAVS.

Keywords:

Immunology
Cell biology
Immunity
Biology
Protein biosynthesis
Phosphorylation
Transfer RNA
GLUTAMYL-PROLYL-tRNA SYNTHETASE
Biochemistry
RNA-binding protein
Signal transduction
Ubiquitin
Amino Acyl-tRNA Synthetases
Viral replication

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