Visible-Light Enabled Aminocarbonylation of Unactivated Alkyl Iodides with Stoichiometric Carbon Monoxide for Application on Late-Stage Carbon Isotope Labeling

A visible-light mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amount of carbon monoxide is presented. The method provides a mild, one-step route to [carbonyl-13/14C]alkyl amides; thereby, reducing radioactive waste, and handling of radioactive material. Easily accessible and low cost equipment and palladium catalyst were successfully used for the synthesis of a wide range of alkyl amides.