Kronik karaciğer hastalığı olan çocukluklarda doğal antikoagülan düzeyleri Özgün Araştırma

Summary Aim: The aim of this study was to evaluate the serum levels of natural anticoagulants and their possible role as a marker in determining the severity of liver disease Material and Method: Protein C protein S and antithrombin levels were measured in 44 children with hepatit B related chronic liver disease 26 chronic hepatitis 18 cirrhosis and in 20 healty controls using an automated functional clotting assay automated functional assay and chromogenic assay respectively Results: In comparison with chronic hepatitis patients cirrhotics had significantly decreased protein C levels There was no significant difference in protein S and antitrombin levels between these two groups All anticoagulants were significantly reduced in chronic liver patients in comparison to the control group Conclusions: In children with chronic liver disease reduction of natural anticoagulants is common and protein C levels may used as a marker of hepatocellular damage Turk Arch Ped 2010; 45: 238 41 Key words: Childhood chronic hepatitis liver cirrhosis natural anticoagulants