Understanding Treatment Tolerability in Older Adults With Cancer.

Key Objective: What do we know about cancer treatment tolerability in older adults and where are the gaps? Knowledge generated: While there is strong evidence that geriatric assessment findings can be helpful in predicting treatment tolerability in older adults with cancer, more research is needed on treatment tolerability assessment, monitoring, and mitigation efforts for older adults during and after completion of treatment. A model is proposed to guide research efforts and clinical care that incorporates multiple tolerability aspects and highlights the patient’s experience and functional status as important endpoints. Relevance: Incorporating patient reported outcomes, functional evaluation, as well as adverse event data provides a more comprehensive and accurate understanding of treatment tolerability in older adults.