Studies in the relationship between molecular structure and chromatographic behaviour : X. The chromatographic behaviour of alkylphenols, some arylphenols and some alkoxyphenols on thin layers of cellulose impregnated with polyamide☆

Abstract Seventy-six alkyl-, aryl-, and alkoxyphenols have been chromatographed on polyamide—cellulose with a non-aqueous mobile phase and an aqueous mobile phase. Removal of the phenol from the surface is dependent upon the solvation either of the hydrophobic part of the molecule by the non-aqueous phase or the phenolic group by the aqueous mobile phase. The behaviour of the phenols is modified by steric effects. The M artin additivity principle applies approximately for all phenols chromatographed with an aqueous mobile phase, and for ortho -phenols chromatographed with a non-aqueous mobile phase. The relationship is not valid for non- ortho -phenols chromatographed with a non-mobile phase.