The Effects of Tramadol Infiltration on Wound Healing in Rats

Purpose : Infiltration of a local anesthetic to provide postoperative analgesia is a frequently used method. However the infiltrated agents may have negative effects on wound healing. This study aimed to investigate the effects of tramadol, a weak opioid with a local anesthetic effect, on wound healing. Methods : Wistar albino rats were used in the study. Tramadol and saline infiltration was randomly performed on the left and right backs of rats. Following a linear incision, the site was sutured. A follow-up was conducted after seven days, and the tissue samples from both locations were extracted for histopathological examinations (fibrotic index : no fibrosis 0, mild 1, moderate 2, severe 3) and hydroxyproline measurements. Results : The hydroxyproline level found in the tramadol group was 0.060 ± 0.04 ng/mg.protein. In the control group the hydroxyproline level was 0.012 ± 0.01 ng/mg.protein (p = 0.01). The fibrotic index levels in the tramadol group were higher than the control group (p < 0.001). Conclusion : It was concluded that tramadol infiltration in a surgical incision site has no adverse effect on wound healing.