377 GENOMIC CHANGES IN HEPATITIS B VIRUS ASSOCIATED WITH THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA: A COHORT STUDY IN PATIENTS WITH CHRONIC HEPATITIS B OF GENOTYPE C2

Conclusions: Prediction models that include age, platelet counts, HBVDNA, and core promoter mutations had high reproducibility and sensitivity to identify patients with risk for the development of HCC. These models may be used to extract patients at risk for HCC out of those excluded from therapy by treatment guidelines. The NUC therapy significantly reduced the incidence of HCC among patients with high risk for HCC.