Bioinformatics insight into glycosyltransferase gene expression in gastric cancer: POFUT1 is a potential biomarker

Abstract Aberrant glycosylation plays an important role in the progression of gastric cancer. Although many enzymes are involved in glycoconjugate synthesis, little information is known about glycosyltransferase (GT)’s alteration in gastric cancer. To give an insight into the differential expression of GTs as obtained from the TCGA database, bioinformatics analysis of 415 gastric cancer samples and 35 normal samples was performed. Using a 0.6-fold change threshold to compare GT expression in normal and cancer tissues, it was noted that 36 GTs were upregulated including POFUT1 and 30 GTs were downregulated in cancer tissues ( P P P  = 0.026, 0.042) as well as poor differentiation ( P  = 0.031). No correlation was observed between POFUT1 expression and age, gender, stage, and Lauren classification. These results suggested that POFUT1 is increased and may serve as a potential biomarker in gastric cancer.