Clinical observation of chemo-radiotherapy for locally advanced non-small cell lung cancer

Objective To evaluate the clinical effect and toxicity of concurrent chemo-radiotherapy and sequential chemo-radiotherapy in treating non-small cell lung cancer(NSCLC).Methods Sixty NSCLC patients,of whom 31 with squamous carcinoma,23 with adenocarcinoma,2 with large cell carcinoma and 4 with anaplastic carcinoma.These patients were also staged by CT or MRI,15 with Ⅲa stage,30 with Ⅲb stage,15 with Ⅳ stage.The age was between 21 to 86,Kamofsky apart ≥ 70.All these patients were randomly divided into two groups,the sequential chemoradiotherapy group A(n=30),thus chemotherapy + radiotherapy + chemotherapy;and the concurrent chemoradiotherapy group B(n=30),thus(Monday to Friday radiotherapy,Saturday chemotherapy)+ chemotherapy.Results Short-term effect,group B was better than group A in PR + CR.Group B was higher than group A in the toxicity of nausea and vomitting.Group A was higher than group B in the toxicity of leukocytonpenia.Conclusion Better short-term effect of locally advanced non-small cell lung cancer could be achieved by concurrent chemo-radiotherapy as compared with sequential chemo-radiotherapy though at the correspondent level of toxicity.Long-term surrival and possible specific injury await further study. Key words: Non-small cell lung carcinoma/radiotherapy; Non-small cell lung carcinoma/chemotherapy; Concurrent chemo-radiotherapy; Prognosis