A Comprehensive Review of Thrombogenic Mechanisms in APS

The antiphospholipid syndrome (APS) is an acquired thombophilia, which is characterized by one or more thrombotic episodes and obstetric complications in the presence of antiphospholipid (aPL) antibodies (Abs). aPL Abs are detected by laboratory tests such as lupus anticoagulant (LA), anticardiolipin (aCL) and anti- 2-glycoprotein I ( 2GPI) Abs. This article reviews the most current pathophysiological aspects of APS with emphasis in thrombotic and pro- inflammatory mechanisms mediated by aPL antibodies.