Views of Graham Challenged

In Reply.— Dr Sandyk suggests that the increased number of apneas seen in sleeping infants after the administration of phenothiazine could be related to an increase in endogenous opioids. If validated, this suggestion could be of interest for the understanding of the mechanisms inducing central and obstructive sleep apneas. As suggested naloxone could be tried in case of phenothiazine-induced apneas, but it seems advisable to systematically avoid the administration of phenothiazine-containing drugs to children younger than 2 years of age.