Scopolamine hydrobromide orally disintegrating microencapsule tablets based on NIMS system

2009 
The invention relates to the technical field of medicines, particularly to scopolamine hydrobromide orally disintegrating microencapsule tablets based on a NiMS system and a preparation method thereof. The orally disintegrating microencapsule tablet provided by the invention is prepared by the NiMS system containing scopolamine hydrobromide and auxiliary materials. The auxiliary materials comprise microcrystalline cellulose, sodium carboxymethyl starch, mannitol, lactose, xylitol, magnesium stearate, superfine silica powder, etc. The copolamine hydrobromide orally disintegrating microencapsule tablet provided by the invention can be taken conveniently, and disintegrated rapidly in mouth by solvent of saliva without needing to drink water. The NiMS system further has a slow release effect,thereby not causing abnormal high blood drug concentration, reducing drug side effects, reducing local stimulation, and meeting requirements for special conditions and special groups, particularly the aged, children and patients who swallow difficultly.
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