Benzofuran derivatives and benzothiophene useful in treating hyperproliferative disorders.

A compound of formula ** ** wherein X is selected from O and S; R1 is selected from H, (C1-C6), C (O) (C1-C6), and benzoyl; R2 is selected from phenyl and naphthyl, each optionally substituted with 1, 2 or 3 substituents each independently selected from OH, CN, NO2, (C1-C6) alkyl, (C1-C6), halogen, haloalkyl (C1-C6), halogen-alkoxy (C1-C6), C (O) RA, C (O) NRBRB, NRBRB, NH [alkyl (C1- C6) alkyl] 0-1S (O) 2RB, NH [alkyl ( C1-C6)] 0-1C (O) RA, and NH [(C1-C6) alkyl] 0-1C (O) ORB, a heterocycle selected from a 6-membered heterocycle, a 5-membered heterocycle and a bicyclic heterocyclic condensate, each heterocycle optionally substituted with 1, 2 or 3 substituents each independently selected from OH, CN, NO2, (C1-C6) alkyl, (C1-C6), halogen, halogen- (C1-C6), halogen- (C1-C6), C (O) RA, C (O) NRBRB, NRBRB, NH [(C1-C6) alkyl] 0-1S (O) 2RB, NH [alkyl (C1- C6) alkyl] 0 1C (O) RA, and NH [(C1-C6) alkyl] 0-1C (O) ORB, RA is in each case formaindependiente H, (C1-C6) alkyl, (C1-C6), or NRBRB (C1-C6) alkyl, said alkyl optionally substituted c on OH, C (O) RB, halogen, (C1-C3), and NRBRB; RB at each occurrence is independently H, (C3-C6), and (C1-C6) alkyl, said alkyl optionally substituted with OH, = O, (C1-C6), NH-alkyl (C1-C3 ), N [(C1-C3)] 2, and NC (O) -C (C1- C3); or a salt or pharmaceutically acceptable ester thereof.