Examination of possible role of the chlamydial stress proteins in pathogenesis of ectopic pregnancy
2014
Introduction. Chlamydia trachomatis infections are the most prevalent
bacterial sexually transmitted infections recognized throughout the world. In
the last few years, several studies have indicated that predisposition of C.
trachomatis to persist within the host cell is recognized as a major factor
in the pathogenesis of chlamydial infection. During persistent chlamydial
infection, the stress protein hsp60 is synthesized continually as
immunopathologic antigen. Antibodies to hsp60 are found in women with tubal
occlusion, but these antibodies are not detected in women with the acute C.
trachomatis infection, which indicates that hsp60 has an important role in
pathogenesis of persistant chlamydial infection. Objective. The aim of this
study was to determine the role of chlamydial stress proteins (heat shock
proteins) in pathogenesis of ectopic pregnancy. Methods. The study included
40 women with ectopic pregnancy (experimental group) and 34 women with normal
pregnancy (control group). C. trachomatis was detected in endocervical smears
by direct immunofluorescence test, while specific antibodies against
Chlamydia spp. and against hsp60 were detected by ELISA. Results. DIF method
detected the presence of C. trachomatis in 12.5% of women with the ectopic
pregnancy and 17.6% of women with normal pregnancy. IgG antibodies against
Chlamydia spp. were found in 57.5% of women with the ectopic pregnancy and
26.5% of women with normal pregnancy. IgA antibodies were positive in 37.5%
of women with the ectopic pregnancy and 2.9% of women with normal pregnancy.
IgG antibodies against hsp60 were positive in 37.5% of women with the ectopic
pregnancy and 14.7% of women with normal pregnancy. Conclusion. The results
of this study have proven the correlation between the ectopic pregnancy and
the presence of IgG antibodies to chlamydial hsp60.
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